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KMID : 0438420140210040249
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Korean Journal of Bone Metabolism
2014 Volume.21 No. 4 p.249 ~ p.255
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Effect of Zoledronate on the Expression of Vascular Endothelial Growth Factor-A by Articular Chondrocytes and Synovial Cells: An in Vitro Study
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Yi Jin-Woong
Lee Woo-Suk
Kim Sang-Bum
Heo Youn-Moo
Chae Dong-Sik
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Abstract
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Background: The aim of this in vitro study was to determine the effect of zoledronate, which is frequently used to treat osteoporosis, on osteoarthritis by analyzing zoledronate-induced expression of vascular endothelial growth factor-A (VEGF-A) in chondrocytes and synovial cells.
Methods: After chondrocytes and synovial cells were separated and cultured, zoledronate was added, and VEGF-A and pigment epithelium-derived factor (PEDF) expression were quantified by real-time polymerase chain reaction and Western blotting.
Results: There was no significant difference in the expression of VEGF-A mRNA in chondrocytes between the zoledronate group and the control group on the 8th day of culture. The expression of both VEGF-A and PEDF mRNA in synovial cells was significantly decreased in the zoledronate group (P<0.05).
Conclusions: Zoledronate decreases the expression of VEGF-A in synovial cells and may affect the development and progression of osteoarthritis.
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KEYWORD
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Chondrocytes, Osteoarthritis, Synovial cells, Vascular endothelial growth factor-A, Zoledronate
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